Amy Schumer's Dramatic Weight Loss Stuns Fans, Here's What She Revealed About Using Ozempic

Amy Schumer, comedian and actress, is once again the topic of discussion on the internet. But this time, it is not about her new comic act or unfiltered comments, but rather her dramatic weight loss, which has left fans stunned. The actress has always been known for embracing body positivity and honesty about her health journey. Recently, she surprised her followers after appearing noticeably slimmer in new photos from her trip to Las Vegas, sparking curiosity about whether she had used some kind of artificial method to achieve the slim appearance. Well, here's what she had mentioned about it.

Amy Schumer's dramatic weight loss during her Las Vegas vacation leaves the internet talking

Amy Schumer recently took to her Instagram handle on October 4, 2025, to share a glimpse of her girls' trip with friends, Alex Saks and Jillian Bell. In the photos, Amy looked more confident and relaxed in a Miu Miu button-down mini shirt dress, paired with sleek black heels. However, more than her appearance, it was Amy's toned legs and her glowing smile that instantly caught everyone's attention. 

Soon, Amy's dramatic weight loss sparked an outpouring of admiration in the comments. Fans and celebrities alike couldn't help but praise the diva. Skincare expert, Georgia Louise, commented, "Amy… legs need to come out more!!!" On the other hand, filmmaker, Lee Daniels playfully wrote, "Skinnnnnnnny mommmmma." Meanwhile, The Real Housewives of New Jersey star, Margaret Josephs, chimed in and wrote, "Ok legs for days!!" agreeing with what many fans felt after seeing the star's stunning new look.

Take a look at her post here. 

Amy Schumer opened up about her experience with weight-loss medications 

Amy Schumer has always been candid about her health struggles and weight journey. According to People, she once revealed that she underwent liposuction in 2022. Next, she experimented with weight-loss medications such as Ozempic and Mounjaro. However, her experience was unlike that of others. During an interview on The Howard Stern Show earlier in 2025, Amy shared that she tried using Ozempic nearly three years ago. However, she was unable to manage the major side effects on her health. Sharing her experience, Amy said:

"I was bedridden. I was vomiting, and then you have no energy. Other people take it, and they're all good. So, God bless them."

Furthermore, Amy Schumer explained that her GDF15 gene, which causes severe nausea, made the medication unbearable. "I couldn't even throw a ball back and forth with my son," she revealed. For those unaware, Amy Schumer shares a six-year-old son, Gene David, with her husband, Chris Fischer. Since then, Amy has switched to hormone therapy for premenopause and Mounjaro, which she says helps with energy, skin, and hair. Sharing more about her new experience, Amy penned: 

"I'm having a really good experience, so I wanted to keep it real with you about that."

More about Amy Schumer 

Amy Schumer has built a successful career as one of Hollywood's boldest voices in comedy. She first rose to fame on NBC's Last Comic Standing. Soon, she followed it with critical success for her sketch show, Inside Amy Schumer. Amy's 2015 film, Trainwreck, earned her a Golden Globe nomination. She also starred in Snatched and I Feel Pretty. Amy had also received a Tony Award nomination for her Broadway debut in Steve Martin's Meteor Shower, as well as two Grammy nominations for her comedy specials and audiobook.

What do you think about Amy Schumer's dramatic weight transformation?

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